Category: Autoimmunity
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifactorial and poorly understood disabling disease. We present epidemiological, clinical and experimental evidence that ME/CFS constitutes a major type of adverse effect of vaccines, especially those containing poorly degradable particulate aluminum adjuvants.
14-3-3h may represent a useful diagnostic biomarker for rheumatoid arthritis (RA). We assessed the prevalence and serum levels of 14-3- 3h in patients with RA and in patients with other rheumatic diseases. Serum levels of 14-3-3h were measured in 96 patients with RA, in 101 patients with other rheumatic diseases, and in 66 healthy subjects.
Specific differences in cancer risk have been observed between systemic lupus erythematosus (SLE) patients and the general population. In past decades, various studies have investigated the relationship between SLE and malignancy.
Although anti-TNFα agents have revolutionized the treatment of many inflammatory diseases, various concerns have been reported regarding the risks of cancer development, as well as the acceleration of the progression of subclinical, pre-existing malignancies.
Autoimmune myelofibrosis is a distinct clinicopathological entity that occurs with autoimmune disorders. We report the case of a 44-year-old woman admitted with pancytopenia and clinical features of systemic lupus erythematosus, Sjogren’s syndrome and antiphospholipid antibodies syndrome.
Autoimmune diseases are characterized by the irregular functioning of the immune system that leads to the loss of tolerance to self-antigens. The underlying nature of autoimmune diseases has led to speculation that the risk of malignancy might be higher or lower in patients with such diseases.
The aim of the present study was to evaluate whether circulating serum ferritin and adiponectin (ADP) in the serum and synovial fluid correlate with cartilage damage severity assessed by arthroscopy in patients with knee osteoarthritis.
Systemic lupus erythematosus (SLE), presenting with new onset or worsening neuropsychiatric (NP) symptoms, is a challenge in clinical practice. Mimickers such as infections, drug-induced side effects, metabolic abnormalities, malignancies, and alcohol-related disorders have to be excluded, before attributing the manifestations to disease activity
To study the role of Toll-like receptor (TLR) 2 in Familial Mediterranean fever (FMF) inflammatory process. Methods: TLR2 expression on monocytes of FMF attack-free patients (n ¼ 20) and the effect of sera of FMF patients with an acute attack (n ¼ 9) on TLR2 expression on monocytes of healthy donors were studied by flow cytometry (FACS).
Little is known about the relationship between epilepsy and SSc. Our study included 2431 SSc patients and 12,710 age- and sexmatched controls. In 209 controls (1.6%) and 66 SSc patients (2.7%), epilepsy diagnosis was made (not significant).