Cancer and autoimmune diseases are the two devastating conditions that together constitute a leading health problem worldwide. The rising burden of these disorders in the developing world demands a multifaceted approach to address the challenges it poses.
5 days ago
Immune checkpoint inhibitors block the checkpoint molecules. Different types of cancer immune checkpoint inhibitors have been approved recently: CTLA-4 monoclonal antibodies (as ipilimumab); anti-PD-1 monoclonal antibodies (as pembrolizumab and nivolumab); and anti-PD-L1 monoclonal antibodies (as atezolizumab, avelumab, and durmalumab)
7 days ago
Over recent decades, many clinical trials on curcumin supplementation have been conducted on various autoimmune diseases including osteoarthritis, type 2 diabetes, and ulcerative colitis patients. This review attempts to summarize the highlights from these clinical trials.
13 days ago
Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome
composition and prevalence of Prevotella spp. in a group of individuals at increased risk for RA, but prior to the development of the disease.
Immunotherapy is an umbrella term used to describe therapies that directly target the immune system to combat disease. For many years, immunotherapy has mainly been used to diminish immune responses in diseases traditionally classified as immunemediated, such as autoimmunity and allergy, and to promote tolerance to transplanted tissues and organs.
Primary Sjo¨gren syndrome (pSjS) is a systemic autoimmune disease that may be expressed in many guises, with a clinical spectrum extending from sicca symptoms to systemic involvement
Autoimmune polyendocrine syndrome type 2 (APS-2) is a polygenic disease in which HLA alleles and non-HLA genes determine the targeting of specific tissues by autoreactive T cells, leading to organ-specific autoimmunity.
Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS). We sought to determine whether there are any associations between SBI and depression, fibromyalgia and CFS in a rheumatology clinic population.
Oncology has recently undergone a revolutionary change with the widespread adoption of immunotherapy for many cancers. Immunotherapy using monoclonal antibodies against checkpoint molecules, including programmed death (PD)-1, PD ligand (PD-L)1, and cytotoxic T lymphocyte-associated antigen (CTLA)-4, is effective in a significant subset of patients.
Resveratrol (RSV), a naturally occurring polyphenol, has been found to have potent antioxidant, anti-inflammatory, and anticancer effects. Recently, RSV was reported as a new potential agent to suppress inflammation of collagen-induced arthritis in a mouse model. Nevertheless, the clinical benefits of RSV in the management of rheumatoid arthritis (RA) were not studied.