The main objective of this study was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role.
Autoantibody specificity and disease subtype are biologically meaningful filters that may inform cancer risk stratification in patients with scleroderma. Future research testing the value of targeted cancer screening strategies in patients with scleroderma is needed. Recent studies that demonstrate autoantibodies are powerful tools to interrogate molecular events linking cancer and the development of autoimmunity in scleroderma.
Natural autoantibodies/natural autoimmunity forms a network that serves to protect the organism from outer and inner danger but may also contribute to autoimmune disease. This vital component of the immune system deserves, we think, much greater attention than it currently attracts. A better understanding of how natural autoimmunity contributes in the function of the immune system is needed and how the expansion of this process leads to autoimmune disorders is an intriguing question which we will address in this article.
We postulated that both the presence of adjuvants and insufficient levels of vitamin D may result in the development of autoimmunity in patients with autoimmune/ inflammatory syndrome induced by adjuvants (ASIA) in relation to silicone implant incompatibility.
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld’s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry
During the last few years, a relationship between smoking and autoimmunity has been demonstrated. Smoking habit is emerging as a possible environmental trigger for several autoimmune diseases.
As autoantibodies play a role in the newly proposed classifications, it is expected that measurement of myositis-specific autoantibodies will be increasingly introduced in clinical practice.
Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies against phospholipids and phospholipid-binding proteins.
The present study aims to investigate which autoantibodies are associated with the pregnancy outcome of patients undergoing first
Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We evaluated the presence of anti-HMGCR autoantibodies in sera samples from 13 statin-exposed patients who were suspected of having IMNM, 38 patients with different inflammatory and autoimmune rheumatic diseases and 29 healthy subjects.