Hyperprolactinemia is a relatively common endocrinopathy seen in
clinical practice, with prevalence ranging from 0.4% in healthy population to 5% in family planning clinics. Pregnancy and lactation are the most common causes of physiologic hyperprolactinemia with levels up to 207 ng/mL being reported.
Prolactin (PRL) elevation in patients with prolactin-secreting pituitary tumors has been linked to an increased prevalence of thyroid autoantibodies. However, the effects of antipsychotic drug-induced hyperprolactinemia (HPRL) on the development of thyroid autoimmunity and also of other autoimmune phenomena have not been previously studied.