Primary Sjögren’s syndrome is a systemic autoimmune disease
characterised by chronic inflammation of exocrine glands,
primarily the salivary and lacrimal glands. In the glands, ectopic
lymphoid tissue may form, with germinal centre-like structures
promoting B-cell DNA rearrangements and Ro/SSA and La/
SSB autoantibody production
Recently, many scientists have focused on the importance of the commensal bacteria
in the pathogenesis of several diseases, including autoimmune diseases. The aim of
this review is to describe the main alterations of the microbiome that occur into the
autoimmune diseases (1).
Identification of a novel autoantibody against self-vimentin specific in secondary Sjögren’s syndrome
The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic
H1N1 vaccination in Sjögren’s syndrome triggers polyclonal B cell activation and promotes autoantibody production.
Objectives Vaccination of patients with rheumatic disease has been reported to result in lower antibody titres than in healthy individuals. However, studies primarily include patients on immunosuppressive therapy. Here, we investigated the immune response of treatment-naïve patients diagnosed with primary
Sjögren’s syndrome (pSS) to an H1n1 influenza vaccine.