Regulatory T-cells (Tregs) can facilitate immune evasion by tumor cells by dampening anti-tumor immunity. Reduced Teff/Treg ratio and enhanced Treg functional activity have been observed in patients suffering from different types of cancers, and attenuated Treg numbers/functions can serve as prognostic indicators.
Autoimmune disease are brought about by the inability of our immune system to identify self-antigens due to intrinsic loss of tolerance. Autoimmune diseases can be classified into either systematic or organspecific diseases. The central dogma in autoimmune diseases is their etiopathogenesis. Large strides in understanding the complex processes that drive disease emergence have been made in the past decades, however ongoing investigation is warranted. The current paradigm in disease etiology points towards the complex interplay between environmental triggers and epigenetic deregulations in genetically susceptible
hosts. A variety of environmental factors have been proposed including viral infections, exposure to smoke, hormones, stress,
drugs, pollutants and dietary factors among others.
Oral NaHC0 3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted
via Mesothelial Cells
E. granulosus is very complex multicellular parasite. As many pathogens is highly immunogenic for human host. Thus, the host immunity play a most important role in host-parasite relationship in human ehinococcosis. The secretory and excretory products from parasite influences immune and immune competent cells in human host and stimulate humoral and proinflammatory cell-mediated immune responses, releasing of significant antibody production, and activate T cells and other antigenpresenting cells in human host.
A review of the recent literature on immunological changes in CVD, RA, and CMV infection provides strong evidence that expansions of cytotoxic CD4 + CD28−T cells in RA and other chronic inflammatory conditions are limited to CMV-infected patients and driven by CMV infection. They are likely to be responsible for the excess CV mortality observed in these situations. The CD4+CD28− phenotype convincingly links CMV infection to CV
mortality based on a direct cellular-pathological mechanism rather than epidemilogical association.
We aimed at investigating whether the frequency and function of T helper 17 (Th17) and regulatory T cells (Treg) are affected by a restriction of dietary sodium intake in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
In the context of autoimmunity, many studies support the existence of an immunomodulating role of vitamin D, which has been shown to have an inhibitory effect on type 1 T helper cells (Th1), cells that have
been previously associated with autoim-mune processes, and specifically in organ-specific autoimmune diseases.