The pro-inflammatory cytokine interleukin(IL)-17 and IL-17-producing cells are important players in the pathogenesis of many autoimmune/inflammatory diseases. More recently, they have been associated with liver diseases. This review first describes the general knowledge on IL-17 and IL-17 producing cells.
Autoantibodies targeting self-antigens are hallmarks of many systemic and organ-specific autoimmune diseases. In a clinical laboratory setting, autoantibodies against nuclear and some cytoplasmic antigens are routinely screened by the indirect immunofluorescence assay (IFA) on HEp-2 cells (HEp-2-IFA).