A growing number of studies have investigated the malignancy risk associated with systemic lupus erythematosus (SLE), and our review will focus mainly (though not exclusively) on studies published in the past year.
Breast implant–associated anaplastic large cell lymphoma (ALCL) is a CD30+, ALK−, T-cell– derived lymphoma within the nation-Hodgkin.lymphoma group. To date, all patients with breast implant-associated ALCL have had prolonged exposure to textured implants.
Primary Sjo¨gren syndrome (pSjS) is a systemic autoimmune disease that may be expressed in many guises, with a clinical spectrum extending from sicca symptoms to systemic involvement
This study found no association between the presence of ACPAs, other autoantibodies commonly occurring in rheu- matological diseases, or cigarette smoking, and lymphoma risk in RA. These results suggest that other mechanisms are involved in the development of lymphoma in patients with RA, and that the search for biomarkers that can predict development of lymphoma in RA must be continued.
Autoimmune conditions and their treatments may be associated with an increased risk of certain malignancies.
Anti-cyclic citrullinated peptide antibodies, other common autoantibodies, and smoking as risk factors for lymphoma in patients with rheumatoid arthritis
Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may ’bleed’ and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and
can be detected in tissues and the central nervous system. Autoimmune/inflammatory syndrome by adjuvants (ASIA), allergies, autoimmune diseases, immune deficiencies and lymphomas occur in patients with SBIs. There is a need for adequately adjusted epidemiological studies to ascertain the frequency of these diseases. Explantation of the breast implants, however, should be advised to patients with complaints,
as 60–80% of patients show an amelioration of the signs and symptoms after explantation.
A case of a 16-year-old female with polyarticular juvenile idiopathic arthritis (JIA) since the age of 4 years is reported here. This patient also suffered from multiple congenital anomalies. On long-term treatment with oral methotrexate (MTX) and etanercept, multiple subcuta-neous nodules were detected, which were accompanied by increased lactate dehydrogenase and uric acid levels. A biopsy of the largest nodule revealed Epstein–Barr (EB) virus-positive diffuse large B-cell lymphoma (DLBCL).