The Microbiome and Systemic Lupus Erythematosus
12 days ago
The assessment of skin fibrosis is vital for the diagnosis and monitoring of treatment in the systemic sclerosis (SSc)—a severe autoimmune disease.
Granulomatosis with polyangitis (GPA; Wegener’s) is a systemic vasculitis characterised by granuloma- tous inflammation and up to 90% of participants will develop sinonasal inflammation during the course of the disease. Despite the many therapeutic advances in the management of GPA, relapses remain a significant issue and, in particular, disease activity in the sinuses and nose often persists when a patient is otherwise in clinical remission.
Smoking Cessation Induces Profound Changes in the
Composition of the Intestinal Microbiota in Humans
The gut microbiome is increasingly recognized as having fundamental roles in human physiology and health. A central question is the extent to which microbiome composition is determined by host genetics. Previous studies have identified several heritable bacterial taxa but the combined bacterial abundance accounted for by them has not yet been quantified.
Background:Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure. Immunosuppressants used in treatment put patients at a higher risk of infections. New knowledge of disease modulators, such as symbiotic bacteria, can enable fine-tuning of parts of the immune system, rather than suppressing it altogether.
Objective Altered microbiota composition or dysbiosis is suspected to be implicated in the pathogenesis of chronic inflammatory diseases, such as spondyloarthritis (SpA) and rheumatoid arthritis (rA).
Altered microbiota composition or dysbiosis is suspected to be implicated in the pathogenesis of chronic inflammatory diseases, such as spondyloarthritis (SpA) and rheumatoid arthritis (rA).