Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of systemic autoimmune diseases (collectively referred to as myositis), which mainly include the subtypes of polymyositis, dermatomyositis, immune-mediated necrotizing myopathy (IMNM) and sporadic inclusion body myositis (sIBM).
Narcolepsy type 1 (NT1) is a chronic sleep disorder characterized by loss of hypocretin-producing neurons. Increased NT1 incidence was observed in Sweden following mass-vaccination with PandemrixVR. Genetic association to HLA DQB106:02 implies an autoimmune origin, but target autoantigen remains unknown.
Close to 30 years ago we [Y.S. et al.] came up with the notion that autoimmune diseases share a common background which they had termed the mosaic of autoimmunity.
The treatment of autoimmune disease is a challenge and priority as they affect 50 million individuals in the United States, and currently they collectively are the third most common disease category.
Autoantibodies for Cardiac Channels and Sudden Cardiac Death and its Relationship to Autoimmune Disorders
The main objective of this study was to determine the prevalence of anti-dense fine speckled (DFS70) antibodies in a stable population of undifferentiated connective tissue disease (UCTD) to better define their potential role.
Autoantibody specificity and disease subtype are biologically meaningful filters that may inform cancer risk stratification in patients with scleroderma. Future research testing the value of targeted cancer screening strategies in patients with scleroderma is needed. Recent studies that demonstrate autoantibodies are powerful tools to interrogate molecular events linking cancer and the development of autoimmunity in scleroderma.
Natural autoantibodies/natural autoimmunity forms a network that serves to protect the organism from outer and inner danger but may also contribute to autoimmune disease. This vital component of the immune system deserves, we think, much greater attention than it currently attracts. A better understanding of how natural autoimmunity contributes in the function of the immune system is needed and how the expansion of this process leads to autoimmune disorders is an intriguing question which we will address in this article.
We postulated that both the presence of adjuvants and insufficient levels of vitamin D may result in the development of autoimmunity in patients with autoimmune/ inflammatory syndrome induced by adjuvants (ASIA) in relation to silicone implant incompatibility.
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld’s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry