In the present review, recent findings regarding autoimmune/inflammatory syndrome by adjuvants (ASIA) are
described. Patients with ASIA present with complaints such as fatigue, cognitive impairment, arthralgias,myalgias, pyrexia, dry eyes, and dry mouth
Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may ’bleed’ and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and
can be detected in tissues and the central nervous system. Autoimmune/inflammatory syndrome by adjuvants (ASIA), allergies, autoimmune diseases, immune deficiencies and lymphomas occur in patients with SBIs. There is a need for adequately adjusted epidemiological studies to ascertain the frequency of these diseases. Explantation of the breast implants, however, should be advised to patients with complaints,
as 60–80% of patients show an amelioration of the signs and symptoms after explantation.