The aetiopathogenesis of rheumatoid arthritis (RA) is thought to result from a multistep process, where environmental factors induce a pathological activation of the immune system in susceptible
individuals. Recent studies have suggested that the initial steps of the pathological autoimmune response originate in mucosal sites, rather than in the joints.
Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome
composition and prevalence of Prevotella spp. in a group of individuals at increased risk for RA, but prior to the development of the disease.
Objective. Prevotella copri, an intestinal microbe, may overexpand in stool samples from patients with new-onset rheumatoid arthritis (RA), but it is not yet clear whether the organism has immune relevance in RA pathogenesis.