Scleroderma renal crisis (SRC) is a severe life-threatening manifestation in patients with systemic sclerosis (SSc). However, the knowledge about risk factors for SRC is limited. We here
determined the frequency of SRC and identified risk factors for the prediction of SRC.
The aetiology of systemic sclerosis (SSc) is unknown, but interactions between environmental factors, including silicone and silica, and epigenetic features are reported to be important.