Autoimmune myelofibrosis is a distinct clinicopathological entity that occurs with autoimmune disorders. We report the case of a 44-year-old woman admitted with pancytopenia and clinical features of
systemic lupus erythematosus, Sjogren’s syndrome and
antiphospholipid antibodies syndrome.
Autoimmune diseases are characterized by the irregular functioning of the immune system that leads to the loss of tolerance to self-antigens. The underlying nature of autoimmune diseases has
led to speculation that the risk of malignancy might be higher or lower in patients with such diseases.
Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin
plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system.
Originally, neutrophil granulocytes were described to phagocytose and kill bacteria. In 2004, a second mechanism in
which neutrophils trap bacteria with extracellular DNA
(NETs) was described by Brinkmann et al.
The pro-inflammatory cytokine interleukin(IL)-17 and IL-17-producing cells are important players in the pathogenesis of many autoimmune/inflammatory diseases. More recently, they have been associated with liver diseases. This review first describes the general knowledge on IL-17 and IL-17 producing cells.
Minocycline is a semi-synthetic antimicrobial which, in addition to its role in infectious disease, has garnered roles in the management of acne vulgaris, acne rosacea, and a variety of novel clinical applications (1). In the context of a potentially expanding population on protracted treatment courses, immune-mediated adverse effects, although rare, remain important to recognize.
Autoimmune/inflammatory syndrome induced
by adjuvants—ASIA—related to biomaterials: analysis of 45 cases
and comprehensive review of the literature
Chronic fatigue syndrome (CFS) is a multifaceted disorder causing profound debilitating fatigue negatively influencing one’s quality of life and functional capacity. CFS is a clinical diagnosis of exclusion and is given when other etiologies for fatigue have been ruled out.
Women with silicone breast implants and autoimmune inflammatory syndrome induced by adjuvants: description of three patients and a critical review of the literature
Genes of the major histocompatibility complex (MHC) (human leukocyte activation, HLA, in humans) and olfactory receptors (ORs) appear to be physically linked.