Autoimmune diseases are characterized by the irregular functioning of the immune system that leads to the loss of tolerance to self-antigens. The underlying nature of autoimmune diseases has
led to speculation that the risk of malignancy might be higher or lower in patients with such diseases.
Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin
plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system.
Originally, neutrophil granulocytes were described to phagocytose and kill bacteria. In 2004, a second mechanism in
which neutrophils trap bacteria with extracellular DNA
(NETs) was described by Brinkmann et al.
Genes of the major histocompatibility complex (MHC) (human leukocyte activation, HLA, in humans) and olfactory receptors (ORs) appear to be physically linked.
With the advent of biological therapies, better outcomes have recently been noted in the management of autoimmune diseases. Nonetheless, recent research highlights the salient role of modifiable behaviors such as physical inactivity on various aspects of the immune system and autoimmune diseases. Physical activity leads to a significant elevation in T-regulatory cells, decreased immunoglobulin secretion and produces a shift in the Th1/Th2 balance to a decreased Th1 cell production.