Rheumatoid arthritis (RA) is characterised by functional disability,
pain, fatigue and body composition alterations that can further
impact on the physical dysfunction seen in RA. RA is also associated with systemic manifestations, most notably an increased risk
for cardiovascular disease
An autoimmune disease develops when the immune system fails to
recognize self from non-self and mounts an immunologic response
damaging its own tissues.
With the advent of biological therapies, better outcomes have recently been noted in the management of autoimmune diseases. Nonetheless, recent research highlights the salient role of modifiable behaviors such as physical inactivity on various aspects of the immune system and autoimmune diseases. Physical activity leads to a significant elevation in T-regulatory cells, decreased immunoglobulin secretion and produces a shift in the Th1/Th2 balance to a decreased Th1 cell production.
This systematic review evaluates whether exercise has a deleterious effect on disease activity in SLE, and explores effects on CV function
and risk factors, physicalfitness and function and health-related measures