There is a need to further characterize the antibody response to vimentin in relation to it possible involvement in pathogenicity of sarcoidosis, and other lung disorders.
The use of vaccines including aluminum (Al)–based adjuvants is widespread among small ruminants and other animals. They
are associated with the appearance of transient injection site nodules corresponding to granulomas.
Dermal fillers are used for multiple cosmetic indications including gluteal and thigh augmentation. Complications, although infrequent, are increasing due to the dramatic growth of dermal filler use
Granulomatosis with polyangitis (GPA; Wegener’s) is a systemic vasculitis characterised by granuloma- tous inflammation and up to 90% of participants will develop sinonasal inflammation during the course of the disease. Despite the many therapeutic advances in the management of GPA, relapses remain a significant issue and, in particular, disease activity in the sinuses and nose often persists when a patient is otherwise in clinical remission.
We provide a comprehensive update on the cellular components and their functional implications in sarcoid granuloma formation, with special emphasis on the specific characteristics of granuloma in acute versus chronic sarcoidosis. Moreover, the specific antigens thought to be involved in both forms of the disease are discussed.