This study presents interferon-alpha (IFN-α)-induced persistent fatigue as a model of CFS. IFN-α, which is used in the treatment of chronic Hepatitis C Virus (HCV) infection, induces persistent fatigue in some individuals, which does not abate post-treatment, that is, once there is no longer immune activation.
Prediction of autoimmune connective tissue disease
in an at-risk cohort: prognostic value of a novel twoscore
system for interferon status