The aetiopathogenesis of rheumatoid arthritis (RA) is thought to result from a multistep process, where environmental factors induce a pathological activation of the immune system in susceptible
individuals. Recent studies have suggested that the initial steps of the pathological autoimmune response originate in mucosal sites, rather than in the joints.
Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome
composition and prevalence of Prevotella spp. in a group of individuals at increased risk for RA, but prior to the development of the disease.
Resveratrol (RSV), a naturally occurring polyphenol, has been found to have potent antioxidant, anti-inflammatory, and anticancer effects. Recently, RSV was reported as a new potential agent to suppress inflammation of collagen-induced arthritis in a mouse model. Nevertheless, the clinical benefits of RSV in the management of rheumatoid arthritis (RA) were not studied.
Pollution has long been incriminated in many cardiovascular and respiratory diseases. More recently, studies evaluated the potential role for particulate pollutants in autoimmune diseases, including rheumatoid arthritis (RA)
14-3-3h may represent a useful diagnostic biomarker for rheumatoid arthritis (RA). We assessed the prevalence and serum levels of 14-3- 3h in patients with RA and in patients with other rheumatic diseases. Serum levels of 14-3-3h were measured in 96 patients with RA, in 101 patients with other rheumatic diseases, and in 66 healthy subjects.
Rheumatoid arthritis (RA) is characterised by functional disability,
pain, fatigue and body composition alterations that can further
impact on the physical dysfunction seen in RA. RA is also associated with systemic manifestations, most notably an increased risk
for cardiovascular disease
Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation.
Our objective was to investigate whether a dietary pattern derived using inflammatory biomarkers is associated with rheumatoid arthritis (RA) risk. We prospectively followed 79,988 women in the Nurses’ Health Study (NHS, 1984–2014) and 93,572 women in the NHSII (1991–2013); incident RA was confirmed by medical records.
In rheumatoid arthritis (RA), immunological triggers at mucosal sites, such as the gut microbiota, may promote autoimmunity that affects joints.
Smoking is Associated with low levels of soluble PD-L1 in Rheumatoid Arthritis