Rheumatoid arthritis (RA) is an autoimmune disease caused by genetic and environmental factors. Infection is proposed to contribute to the pathogenesis. Several viral and bacterial infections, including parvovirus B19, Chikungunya, hepatitis C, Epstein-Barr virus and Porphyromonas gingivalis, have been raised to be associated with RA
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Heterogeneous clinical phenotypes, different patterns of response to
therapy and mosaic severity disease among RA patients had raised the need among clinicians to identify possible response predicting factors and profile single RA patient conditions.
Patients with rheumatoid arthritis (RA) are at increased risk of
mortality, largely attributed to increased cardiovascular (CV) death.
The prevalence of the cardiovascular disease in autoimmune diseases has been underestimated for decades.
The aetiopathogenesis of rheumatoid arthritis (RA) is thought to result from a multistep process, where environmental factors induce a pathological activation of the immune system in susceptible
individuals. Recent studies have suggested that the initial steps of the pathological autoimmune response originate in mucosal sites, rather than in the joints.
Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome
composition and prevalence of Prevotella spp. in a group of individuals at increased risk for RA, but prior to the development of the disease.
Resveratrol (RSV), a naturally occurring polyphenol, has been found to have potent antioxidant, anti-inflammatory, and anticancer effects. Recently, RSV was reported as a new potential agent to suppress inflammation of collagen-induced arthritis in a mouse model. Nevertheless, the clinical benefits of RSV in the management of rheumatoid arthritis (RA) were not studied.
Pollution has long been incriminated in many cardiovascular and respiratory diseases. More recently, studies evaluated the potential role for particulate pollutants in autoimmune diseases, including rheumatoid arthritis (RA)
14-3-3h may represent a useful diagnostic biomarker for rheumatoid arthritis (RA). We assessed the prevalence and serum levels of 14-3- 3h in patients with RA and in patients with other rheumatic diseases. Serum levels of 14-3-3h were measured in 96 patients with RA, in 101 patients with other rheumatic diseases, and in 66 healthy subjects.
Rheumatoid arthritis (RA) is characterised by functional disability,
pain, fatigue and body composition alterations that can further
impact on the physical dysfunction seen in RA. RA is also associated with systemic manifestations, most notably an increased risk
for cardiovascular disease
Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation.