Scleroderma renal crisis (SRC) is a severe life-threatening manifestation in patients with systemic sclerosis (SSc). However, the knowledge about risk factors for SRC is limited. We here
determined the frequency of SRC and identified risk factors for the prediction of SRC.
The aetiology of systemic sclerosis (SSc) is unknown, but interactions between environmental factors, including silicone and silica, and epigenetic features are reported to be important.
Little is known about the relationship between epilepsy and SSc.
Our study included 2431 SSc patients and 12,710 age- and sexmatched controls. In 209 controls (1.6%) and 66 SSc patients
(2.7%), epilepsy diagnosis was made (not significant).
Interstitial lung disease (ILD) is the leading cause of death
in patients with systemic sclerosis (SSc). Randomized controlled trials have favored the use of cyclophosphamide (CYC) for treating SSc-ILD3,4,5. Compared with placebo, 1 year of CYC improved lung function in patients with SSc-ILD in Scleroderma Lung Study (SLS) I3
Increased expression of RNA polymerase 1 (POL1) molecular pathway was reported to be associated with increased disease activity in patients with multiple sclerosis (MS). However, the operating molecular mechanisms that characterize the pattern of acute MS relapse activity has not been thoroughly studied.
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) in which demyelination and neurodegeneration occurs. The immune system of MS patients is characterized by a dysregulation in the balance between pro- and anti-inflammatory immune cells, whereby both the innate and adaptive immune system are involved
SSc is a complex rheumatoid disease characterized by autoimmunity, fibrosis, and vasculopathy. Mouse models provide powerful research tools for exploring the pathogenesis of human diseases
Systemic Sclerosis (SSc) is a rare autoimmune disease that is characterized by progressive skin fibrosis, an obliteration of the microvasculature and an exaggerated extracellular matrix deposition,
which lead to multisystemic dysfunction.
The objective of this article was to establish the clinical course of interstitial lung disease (ILD) in scleroderma related to the presence of anti-PM/Scl antibody compared with anti-Scl-70 in a Spanish cohort. Furthermore, no study has thoroughly investigated the outcome of pulmonary function test in the first group of patients.
Possible relationship between drug exposure and multiple sclerosis (MS) development is insufficiently investigated, and further challenged by the incomplete understanding of MS etiopathogenesis. The study aims to investigate whether drug exposure could contribute to MS, by analyzing worldwide spontaneous reporting archives of adverse drug reaction (ADRs).