Tag: t cell
Giant-cell arteritis (GCA) is the most frequent form of vasculitis in patients over the age of 50. Large- and medium-sized vessels are mainly affected, especially the cranial branches of the external carotid. The aorta and its branches are also involved in 30 to 60% of patients.
5 days ago
 
Despite major recent advances in the therapeutic management of Giant cell arteritis (GCA), the diagnosis accuracy of temporal artery ultrasound remains controversial in this disease. We performed a systematic review to determine the sensitivity, specificity, and summary positive (LR+) and negative (LR-) likelihood ratios of temporal artery ultrasound for the diagnosis of GCA.
05.04.2019
 
Regulatory T-cells (Tregs) can facilitate immune evasion by tumor cells by dampening anti-tumor immunity. Reduced Teff/Treg ratio and enhanced Treg functional activity have been observed in patients suffering from different types of cancers, and attenuated Treg numbers/functions can serve as prognostic indicators.
20.03.2019
 
Some studies suggest that there is an increased risk of malignancies in giant cell arteritis (GCA). We aimed to describe the clinical characteristics and outcomes of GCA patients with concomitant malignancy and compare them to a GCA control group.
27.02.2019
 
Giant—cell arteritis (GCA) is a large—vessel vasculitis usually affecting individuals over 50 years old, typically presenting with unilateral or a bilateral headache, myalgias, fatigue, fever, weight loss, and sometimes acute vision loss.
25.01.2019
 
The pro-inflammatory cytokine interleukin(IL)-17 and IL-17-producing cells are important players in the pathogenesis of many autoimmune/inflammatory diseases. More recently, they have been associated with liver diseases. This review first describes the general knowledge on IL-17 and IL-17 producing cells.
21.01.2019
 
Giant cell arteritis (GCA) is an autoimmune disorder which primarily affects large vessels, whilst inflammatory bowel diseases (IBD) mainly target the gut. Co-existence of the two maladies has been reported sporadically in the literature; therefore the purpose of this study was to assess the authenticity of such an association in a large, cross-sectional study.
27.11.2018
 
Autoimmune disease are brought about by the inability of our immune system to identify self-antigens due to intrinsic loss of tolerance. Autoimmune diseases can be classified into either systematic or organspecific diseases. The central dogma in autoimmune diseases is their etiopathogenesis. Large strides in understanding the complex processes that drive disease emergence have been made in the past decades, however ongoing investigation is warranted. The current paradigm in disease etiology points towards the complex interplay between environmental triggers and epigenetic deregulations in genetically susceptible hosts. A variety of environmental factors have been proposed including viral infections, exposure to smoke, hormones, stress, drugs, pollutants and dietary factors among others.
01.11.2018
 
The treatment of autoimmune disease is a challenge and priority as they affect 50 million individuals in the United States, and currently they collectively are the third most common disease category.
03.10.2018
 
Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure
01.07.2018
 
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