Vitamin D, autoimmunity and recurrent pregnancy loss: More
than an association
Recurrent pregnancy loss (RPL) has a great emotional and psychological
impact on couples. The definition for RPL is still under
We postulated that both the presence of adjuvants and insufficient levels of vitamin D may result in the development of autoimmunity in patients with autoimmune/ inflammatory syndrome induced by adjuvants (ASIA) in relation to silicone implant incompatibility.
Vitamin D may be considered as a pro-hormone which is obtained from 2 distinct sources; to a lesser extent diet, but principally by synthesis in the epidermal layer of the skin after UV exposure.
The role of vitamin D in innate and adaptive immunity is critical. It has been shown that the redirection of human autoreactive T-cells upon interaction with dendritic cells can be modulated by an analog of 1,25-dihydroxyvitamin D3
Our knowledge of the importance of vitamin D has grown rapidly in recent years, as its influences on different organ systems of the body have been studied...
Objectives: To evaluate the vitamin D-dependent mechanisms
of immunity and autoimmunity in different forms of pulmonary
tuberculosis and sarcoidosis.
In the context of autoimmunity, many studies support the existence of an immunomodulating role of vitamin D, which has been shown to have an inhibitory effect on type 1 T helper cells (Th1), cells that have
been previously associated with autoim-mune processes, and specifically in organ-specific autoimmune diseases.
In recent years, there has been a growing interest in the value of vitamin D and its effects on autoimmunity. The aim of this review is to summarize the current knowledge on the association between vitamin D and rheumatoid arthritis (RA) in terms of prevalence, disease activity, clinical expression, serology and gene
polymorphisms of vitamin D receptors.
Vitamin D deficiency as a risk factor for the development of autoantibodies in patients with ASIA and silicone breast implants: a cohort study and review of the literature
Vitamin D and thyroid disease: to D or not to D?